Potential association between frequent nonsynonymous variant of NPPA and cardioembolic stroke.
作者： Jeong-Hyun Kim , Bo-Hyung Jang , Ho Yeon Go , Sunju Park , Yong-Cheol Shin
关键词: Genotype 、 Nonsynonymous substitution 、 Cardiology 、 Case-control study 、 Internal medicine 、 Myocardial infarction 、 Atrial natriuretic peptide 、 Single-nucleotide polymorphism 、 Brain natriuretic peptide 、 Stroke 、 Biology
摘要: Atrial natriuretic peptide (ANP, also known as NPPA) and brain (BNP, NPPB) have been determined genetic factors for several diseases, including stroke myocardial infarction, in human rat models. To investigate the potential association between polymorphisms of NPPA gene a Korean population, nine single-nucleotide (SNPs) NPPB genes were genotyped total 941 subjects, 674 patients (109 hemorrhagic 565 ischemic) 267 unaffected controls. Genotype comparisons targeted alleles revealed that there no significant associations control or among hemorrhagic, ischemic, groups. However, logistic analysis Trial Org 10172 Acute Stroke Treatment (TOAST) classification ischemic stroke, nonsynonymous rs5065 (STOP152Arg) rs5067 3′UTR NPPA, which complete linkage disequilibrium, showed associa...
sci-hub.se 参考文章(38)
Lincoln R. Potter, Andrea R. Yoder, Darcy R. Flora, Laura K. Antos, Deborah M. Dickey, Natriuretic peptides: their structures, receptors, physiologic functions and therapeutic applications. Handbook of experimental pharmacology. pp. 341- 366 ,(2009) , 10.1007/978-3-540-68964-5_15
Matthias SCHMITT, John R. COCKCROFT, Michael P. FRENNEAUX, Modulation of the natriuretic peptide system in heart failure: from bench to bedside? Clinical Science. ,vol. 105, pp. 141- 160 ,(2003) , 10.1042/CS20030044
Baxter Jeffs, James S. Clark, Niall H. Anderson, Julie Gratton, M. Julia Brosnan, Dominique Gauguier, John L. Reid, I. Mhairi Macrae, Anna F. Dominiczak, Sensitivity to cerebral ischaemic insult in a rat model of stroke is determined by a single genetic locus Nature Genetics. ,vol. 16, pp. 364- 367 ,(1997) , 10.1038/NG0897-364
Cristina Vassalle, Maria Grazia Andreassi, Concetta Prontera, Marianna Fontana, Luc Zyw, Claudio Passino, Michele Emdin, Influence of ScaI and Natriuretic Peptide (NP) Clearance Receptor Polymorphisms of the NP System on NP Concentration in Chronic Heart Failure. Clinical Chemistry. ,vol. 53, pp. 1886- 1890 ,(2007) , 10.1373/CLINCHEM.2007.088302
Daiva Rastenyt≐, Jaakko Tuomilehto, Cinzia Sarti, Genetics of stroke--a review. Journal of the Neurological Sciences. ,vol. 153, pp. 132- 145 ,(1998) , 10.1016/S0022-510X(97)00286-4
Giacomo Giacalone, Mohammed Abballa Abbas, Francesco Corea, Prevention strategies for cardioembolic stroke: present and future perspectives. The Open Neurology Journal. ,vol. 4, pp. 56- 63 ,(2010) , 10.2174/1874205X01004020056
Amy I. Lynch, Eric Boerwinkle, Barry R. Davis, Charles E. Ford, John H. Eckfeldt, Catherine Leiendecker-Foster, Donna K. Arnett, Pharmacogenetic Association of the NPPA T2238C Genetic Variant With Cardiovascular Disease Outcomes in Patients With Hypertension JAMA. ,vol. 299, pp. 296- 307 ,(2008) , 10.1001/JAMA.299.3.296
S. John, J. Krege, P. Oliver, Hagaman, J. Hodgin, S. Pang, T. Flynn, O. Smithies, Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension Science. ,vol. 267, pp. 679- 681 ,(1995) , 10.1126/SCIENCE.7839143
J. Alex Viehman, Jeffrey L. Saver, David S. Liebeskind, Sidney Starkman, Latisha K. Ali, Brian Buck, Tannaz Razinia, Bruce Ovbiagele, Utility of urinalysis in discriminating cardioembolic stroke mechanism. JAMA Neurology. ,vol. 64, pp. 667- 670 ,(2007) , 10.1001/ARCHNEUR.64.5.667
Christopher Newton-Cheh, Martin G Larson, Ramachandran S Vasan, Daniel Levy, Kenneth D Bloch, Aarti Surti, Candace Guiducci, Sekar Kathiresan, Emelia J Benjamin, Joachim Struck, Nils G Morgenthaler, Andreas Bergmann, Stefan Blankenberg, Frank Kee, Peter Nilsson, Xiaoyan Yin, Leena Peltonen, Erkki Vartiainen, Veikko Salomaa, Joel N Hirschhorn, Olle Melander, Thomas J Wang, Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure Nature Genetics. ,vol. 41, pp. 348- 353 ,(2009) , 10.1038/NG.328