Neonatal vitamin D status and risk of multiple sclerosis.

摘要: Objective: Low vitamin D status at birth may be associated with risk of adult onset multiple sclerosis, but this link has not been studied directly. We assessed the relation between neonatal concentrations, measured in stored blood samples, and sclerosis. Methods: This was a population-based case-control study Sweden including 459 incident cases sclerosis 663 controls, randomly drawn froma national population registry frequency matched on sex, age, residential area. Results: There no association 25-hydroxyvitamin quintile (crude odds ratio = 1.0, 95% confidence interval 0.68-1.44, for highest compared to lowest). Adjusting number potential confounding factors early life (month birth, latitude breastfeeding) (25-hydroxyvitamin D, sun exposure, intake from dairy products, fatty fish consumption, smoking, body mass index 20 years age) as well ancestry, heredity, socioeconomic group did considerably affect result. Interpretation: At broad level,