Focal cortical dysplasia II-related seizures originate from the bottom of the dysplastic sulcus: A stereoelectroencephalography study.

摘要: Abstract Objectives Focal cortical dysplasia (FCD) II is a frequently observed histopathological substrate in epilepsy surgery. In the present study, we explored spatial distribution of epileptogenic activities across FCD lesions using stereoelectroencephalography. Methods Patients with histopathologically confirmed type FCDs and who had at least one depth electrode that go through wall dysplastic sulcus from surface to bottom were included. The sulci divided into non-bottom parts manually, contacts defined as or according their locations. Factors (bottom location, pathological subtype, magnetic resonance imaging manifestation, presence bottom-of-sulcus dysplasia) potentially associated earliest onset identified by conventional visual analysis, epileptogenicity index (EI), standardized number high-frequency oscillations (HFOs) analyzed. Linear regression analyses between distance (from location analyzed contact sulcus) EI value HFO performed. Results Sixteen patients 19 electrodes containing 112 valid Bottom was sole factor significantly (P  Conclusion Seizure onsets interictal HFOs most often arise part FCD. Significance findings study contribute intracranial selection, trajectory planning, and, later on, resection this kind malformation.