Preoperative elevation of carcinoembryonic antigen predicts poor tumor response and frequent distant recurrence for patients with rectal cancer who receive preoperative chemoradiotherapy and total mesorectal excision: a multi-institutional analysis in an Asian population.

作者: Jong Hoon Lee , Sung Hwan Kim , Hong Seok Jang , Hyuk Jun Chung , Seong Taek Oh

DOI: 10.1007/S00384-012-1584-6

关键词: Total mesorectal excisionCarcinoembryonic antigenPreoperative careHepatologyColorectal cancerMedicineChemoradiotherapyOncologyTumor responseInternal medicinePreoperative chemoradiotherapy

摘要: Purpose This study was conducted to evaluate the significance of carcinoembryonic antigen (CEA) level as a predictor for tumor response chemoradiotherapy (CRT) and prognosticator survival in Asian patients with advanced rectal cancer.

参考文章(22)
Young-Wan Kim, Nam-Kyu Kim, Byung-Soh Min, Hyuk Huh, Jin-Soo Kim, Jeong-Yeon Kim, Seung-Kook Sohn, Chang-Hwan Cho, Factors associated with anastomotic recurrence after total mesorectal excision in rectal cancer patients. Journal of Surgical Oncology. ,vol. 99, pp. 58- 64 ,(2009) , 10.1002/JSO.21166
Hee Jin Chang, Kyung Hae Jung, Dae Yong Kim, Seung-Yong Jeong, Hyo Seong Choi, Young Hoon Kim, Dae Kyung Sohn, Byong Chul Yoo, Seok-Byung Lim, Dae-Hyun Kim, Joong-Bae Ahn, Il-Jin Kim, Jin Man Kim, Wan-Hee Yoon, Jae-Gahb Park, Bax, a predictive marker for therapeutic response to preoperative chemoradiotherapy in patients with rectal carcinoma Human Pathology. ,vol. 36, pp. 364- 371 ,(2005) , 10.1016/J.HUMPATH.2005.01.018
Iris D. Nagtegaal, Phil Quirke, What Is the Role for the Circumferential Margin in the Modern Treatment of Rectal Cancer Journal of Clinical Oncology. ,vol. 26, pp. 303- 312 ,(2008) , 10.1200/JCO.2007.12.7027
Ji Won Park, Seok-Byung Lim, Dae Yong Kim, Kyung Hae Jung, Yong Sang Hong, Hee Jin Chang, Hyo Seong Choi, Seung-Yong Jeong, Carcinoembryonic antigen as a predictor of pathologic response and a prognostic factor in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy and surgery. International Journal of Radiation Oncology Biology Physics. ,vol. 74, pp. 810- 817 ,(2009) , 10.1016/J.IJROBP.2008.08.057
Jong Hoon Lee, Hong Seok Jang, Jun-Gi Kim, Hyun Min Cho, Byoung Yong Shim, Seong Taek Oh, Sei-Chul Yoon, Yeon-Sil Kim, Byung Ock Choi, Sung Hwan Kim, Lymphovascular invasion is a significant prognosticator in rectal cancer patients who receive preoperative chemoradiotherapy followed by total mesorectal excision. Annals of Surgical Oncology. ,vol. 19, pp. 1213- 1221 ,(2012) , 10.1245/S10434-011-2062-Z
Jong Hoon Lee, Dae Yong Kim, Taek-Keun Nam, Sei-Chul Yoon, Doo Seok Lee, Ji Won Park, Jae Hwan Oh, Hee Jin Chang, Mee Sun Yoon, Jae-Uk Jeong, Hong Seok Jang, Long-term follow-up of preoperative pelvic radiation therapy and concomitant boost irradiation in locally advanced rectal cancer patients: a multi-institutional phase II study (KROG 04-01). International Journal of Radiation Oncology Biology Physics. ,vol. 84, pp. 955- 961 ,(2012) , 10.1016/J.IJROBP.2012.01.045
Prajnan Das, John M. Skibber, Miguel A. Rodriguez-Bigas, Barry W. Feig, George J. Chang, Robert A. Wolff, Cathy Eng, Sunil Krishnan, Nora A. Janjan, Christopher H. Crane, Predictors of tumor response and downstaging in patients who receive preoperative chemoradiation for rectal cancer. Cancer. ,vol. 109, pp. 1750- 1755 ,(2007) , 10.1002/CNCR.22625
Yoon-Ah Park, Seung-Kook Sohn, Jinsil Seong, Seung-Hyuk Baik, Kang-Young Lee, Nam-Kyu Kim, Chang-Whan Cho, Serum CEA as a predictor for the response to preoperative chemoradiation in rectal cancer. Journal of Surgical Oncology. ,vol. 93, pp. 145- 150 ,(2006) , 10.1002/JSO.20320
Jong Hoon Lee, Sung Hwan Kim, Jun-Gi Kim, Hyun Min Cho, Byoung Yong Shim, Preoperative Chemoradiotherapy (CRT) Followed by Laparoscopic Surgery for Rectal Cancer: Predictors of the Tumor Response and the Long-Term Oncologic Outcomes International Journal of Radiation Oncology*Biology*Physics. ,vol. 81, pp. 431- 438 ,(2011) , 10.1016/J.IJROBP.2010.05.019
Inti Zlobec, Russell Steele, Carolyn C. Compton, VEGF as a predictive marker of rectal tumor response to preoperative radiotherapy Cancer. ,vol. 104, pp. 2517- 2521 ,(2005) , 10.1002/CNCR.21484