Aberrant glioblastoma neovascularization patterns and their correlation with DCE-MRI-derived parameters following temozolomide and bevacizumab treatment

摘要: Glioblastoma (GBM) is a highly angiogenic malignancy, and its abundant, aberrant neovascularization closely related to the proliferation invasion of tumor cells. However, anti-angiogenesis combined with standard radio-/chemo-therapy produces little improvement in treatment outcomes. Determining reason for failure pivotal GBM treatment. Here, histopathological analysis dynamic contrast-enhanced MRI (DCE-MRI) were used explore effects temozolomide (TMZ) bevacizumab (BEV) on patterns an orthotopic U87MG mouse model at 1, 3 6 days after We found that amount vascular mimicry (VM) significantly increased BEV TMZ inhibited early stage, but microvessel density (MVD) transfer coefficient (Ktrans) derived from DCE-MRI combination therapy slightly prolonged inhibitory effect microvessels. Sprouting angiogenesis was positively correlated Ktrans all groups. The increase VM administration MVD may be responsible resistance. holds great potential as imaging biomarker indicating variation sprouting during drug GBM.