Bifunctional up-converting lanthanide nanoparticles for selective in vitro imaging and inhibition of cyclin D as anti-cancer agents

摘要: Inhibition of the CDK4/cyclin D complex through substrate recruitment site on cyclin positive regulatory subunit is recognised as being a promising anti-cancer target. Specific peptide sequences can be used to selectively disrupt this target, but development peptides anti-tumor agents in vitro/in vivo presents several obstacles. Poor cell internalization, low sensitivity towards enzymatic degradation vivo, and ineffectiveness monitoring via indirect screening are all issues which must overcome. Herein, we describe surface functionalization lanthanide nanoparticles with D-specific prepare novel nanomaterials (UCNPs–P1) target complex. The prepared permeable they display parallel emission spectra vitro an aqueous biological environment. They also dose concentrations under harmless NIR excitation upconversion. Uniquely, addition acting bioimaging probe, UCNPs–P1 exhibits cytotoxicity cancer cells. In light aforementioned properties, functionalized offer first real dual system for imaging simultaneous inhibition division.