Inhibition of quorum sensing in Pseudomonas aeruginosa by sesquiterpene lactones.
作者： Susana Amaya , José A. Pereira , Susana A. Borkosky , Juan C. Valdez , Alicia Bardón
DOI: 10.1016/J.PHYMED.2012.07.003
关键词: Sesquiterpene 、 Antimicrobial 、 Autoinducer 、 Biofilm 、 Pseudomonas aeruginosa 、 Microbiology 、 Virulence 、 Quorum sensing 、 Biology 、 Pancreatic elastase
摘要: Six sesquiterpene lactones (SLs) of the goyazensolide and isogoyazensolide-type isolated from Argentine herb Centratherum punctatum were evaluated on their ability to inhibit virulence factors Pseudomonas aeruginosa ATCC 27853. Although compounds not able completely bacterial growth at 200μg/ml, SLs do altered biofilm formation, elastase activity, production N-acyl-homoserinelactones (AHLs) which are known quorum sensing autoinducers lower concentration. Compounds 2, 3, 5 displayed significant inhibitory effects P. formation 0.5μg/ml being compound 3 (1.32μM) most potent (42%). 4, 6, inhibited 39, 44, 42, 32 35% AHLs 100μg/ml by more than 50% activity 0.5μg/ml. Our results clearly indicated that good candidates for development new antimicrobial agents acting as bactericidal but antipathogenic agents.
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