The DAMA trial: a diet and physical activity intervention trial to reduce mammographic breast density in postmenopausal women in Tuscany, Italy. Study protocol and baseline characteristics.

摘要: UNLABELLED Aims and background. High mammographic breast density (MBD) is an established risk factor for cancer (BC). The influence of diet physical activity (PA) on MBD has long been investigated. In observational study a cohort in Florence, we observed inverse associations between consumption vegetables olive oil moderate leisure-time PA MBD, while high alcohol intake glycemic load diets were positively associated with MBD. We set out to investigate whether dietary interventions able reduce postmenopausal women (>50%). Methods design. DAMA (Diet, Activity MAmmography) trial, factorial randomized trial involving healthy nonsmoking not using hormone replacement therapy having >50%, aimed at evaluating the ability 24-month intervention based moderate-intensity and/or modification focused plant foods low load, saturated fats alcohol, rich antioxidants fiber, percent Participants have 1 4 arms (diet, PA, + control). Dietary habits anthropometry are collected baseline end phase together repeated blood urine samples. primary outcome absolute change as assessed follow-up digital mammograms performed framework local screening program. Results. Of 728 eligible women, 234 (32.1%) agreed participate. did observe any difference across distribution variables interest related lifestyle. Conclusions. may contribute better understanding determinants. This will provide insight into pathogenesis BC allow development strategies prevention high-MBD groups that easily identifiable large-scale programs. TRIAL REGISTRATION NUMBER ISRCTN28492718.