Increase in number of circulating disseminated epithelial cells after surgery for non-small cell lung cancer monitored by MAINTRAC® is a predictor for relapse: A preliminary report

摘要: Lung cancer still remains one of the most commonly occurring solid tumors and even in stage Ia, surgery fails 30% patients who develop distant metastases. It is hypothesized that these must have developed from occult circulating tumor cells present at time surgery, or before. The aim study was to detect such peripheral blood monitor following surgery. 30 treated for lung with were monitored epithelial (CEC) by taking samples before, 2 weeks 5 months after and/or radiotherapy (RT) chemotherapy (CT) combined RT/CT using magnetic bead enrichment laser scanning cytometry (MAINTRAC®) quantification cells. In 86% CEC detected before 100% control group, which consisted 100 normal donors without cancer, 97 % negative CEC. A significantly higher number found preoperatively squamous cell carcinoma than those adenocarcinoma. correlation extent parenchymal manipulation an increase numbers observed limited resections (18/21) whereas pneumonectomy led a decrease (5/8) CEC, third analysis done identified 3 groups patients. group received neo- adjuvant chemo/radiotherapy there evidence monitoring can evaluate effects therapy. Another 7 underwent only showed no signs relapse. 11 had only, (4 initial continuous increase). during 24 months, early relapses Ia adenocarcinoma observed. preceded clinical detection six months. We consider, therefore, complete resection are increased risk