Effect of Nerve Growth Factor on Microtubules: Evidence for a Protective Action against Depolymerization Induced by Calcium Ions or Cold Treatment

摘要: Although the powerful and specific promoting activity of nerve growth factor (NGF) was first reported more than 25 years ago (1), still little is known about its molecular mechanisms physiological action. This frequently case in field hormones factors, whose phenomenological aspects (spectrum actions, number type target cells, etc.) become even decades before understanding their mechanism gap mainly due to lack a precise knowledge how several eukariotic cells respond given external stimulus. The discovery second messengers remarkable exception this rule, but it would be unwise, our opinion, consider them as transducers or amplifiers for all factors.