Schistosome sirtuins as drug targets.
作者： Julien Lancelot , Alejandro Cabezas-Cruz , Stéphanie Caby , Martin Marek , Johan Schultz
DOI: 10.4155/FMC.15.24
关键词: SUPERFAMILY 、 Apoptosis 、 Adult worm 、 Drug 、 Sirtuin 、 Biology 、 Cell biology 、 Rossmann fold 、 Egg laying 、 NAD+ kinase
摘要: … Sirt2, Sirt3, Sirt4 and Sirt6 mainly seem to have roles in suppressing cancer. Sirt2 KO mice develop hepatocellular carcinoma and Sirt 2 … , and either inhibition or activation of their activity …
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