Benefits and applications of microwave-assisted synthesis of nitrogen containing heterocycles in medicinal chemistry

摘要: Nitrogen containing heterocycles are of immense research interest because they often found as naturally occurring bioactive compounds. The prominence N-heterocycles makes it vital to develop methods increase their synthetic efficiencies and probe the effects modifications on biological efficacy. Medicinal chemists have exploited microwave-assisted organic synthesis (MAOS) facilitate development complex heterocyclic structures. MAOS is a growing methodology among medicinal has proven be more efficient in terms reaction yield, time, product purity environmental friendliness for many reactions when compared conventional thermal cycloaddition selective functionalization. importance nitrogen ring systems medicine cannot understated, such shown applicable compounds vitamins, herbicides, anti-fungal agents, anti-bacterial agents anti-cancer other things. significance these applications created an unprecedented need methods. This review presents overview its role recent pressing advancements small- medium-sized heterocycles, including pyrroles, indoles, pyridines, pyrrolidines, imidazoles, pyrazoles, pyrazolines, lactams, 1,2,3-triazoles, which significant scaffolds with uses.