Enantioselective formal hydration of α,β-unsaturated acceptors: asymmetric conjugate addition of silicon and boron nucleophiles.

摘要: The direct enantioselective 1,4-addition of water to α,β-unsaturated acceptors is an open challenge in asymmetric catalysis. Enantioselective conjugate addition either silicon or boron nucleophiles and subsequent enantiospecific oxidative degradation the carbon–element bond represents, however, attractive detour. A single extra step thereby enables indirect enantiocontrolled construction (in a broader sense) aldols from carbonyl carboxyl compounds. While that strategy had been obvious for long time, it was recent stunning progress transition metal-catalysed activation interelement linkages brought about solution long-standing problem. concise introduction existing protocols stereoselective oxygen followed by comprehensive summary rapid advances (and metal-free) transfer nucleophilic onto acceptors.