Adhesion proteins meet receptors: a common theme?

摘要: Receptors tyrosine kinases (RTKs) and cell adhesion molecules (CAMs) present on the surface sense surrounding environment influence fate of cells. For a long time, it was believed that these were working independently sole binding ligand enough to activate RTK. It is now apparent there is, in fact, very tight connection between RTKs CAMs they work concert. The activation, signaling, or internalization RTKs. Some have similar functions are therefore interchangeable. CD44 isoforms exemplify flexibility interactions as can collaborate with several also be substituted by other functions. In instances, not only control activation receptor presenting but regulate downstream signaling organizing signalosome complex. Furthermore, controlled cellular their ligands.