The Pathogenesis and Treatment of the Valvulopathy of Aortic Stenosis: Beyond the SEAS
作者： Sammy Elmariah , Emile R. Mohler
DOI: 10.1007/S11886-010-0089-6
关键词: Calcification 、 Internal medicine 、 Arteriosclerosis 、 Aortic valve 、 Statin 、 Medicine 、 Stenosis 、 Aortic valve stenosis 、 Pathogenesis 、 Calcinosis 、 Cardiology
摘要: Fibrocalcific aortic stenosis (AS) results from an active process similar to atherosclerosis that involves basement membrane disruption, lipid deposition, inflammatory cell infiltration, and calcification. Consequently, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have been extensively studied as potential therapeutic agents capable of slowing the progression AS. However, two randomized trials, SALTIRE SEAS study, showed no benefit with statin therapy for These shed doubt over efficacy AS, although their at early stages valve disease remains possible. In this article, we review pathophysiology fibrocalcific AS discuss future directions its nonsurgical management in post-SEAS era.
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sci-hub.se 参考文章(50)
Rainer Wessely, Albert Schömig, Adnan Kastrati, Sirolimus and Paclitaxel on polymer-based drug-eluting stents: similar but different. Journal of the American College of Cardiology. ,vol. 47, pp. 708- 714 ,(2006) , 10.1016/J.JACC.2005.09.047
Yohan Bossé, Patrick Mathieu, Philippe Pibarot, Genomics : the next step to elucidate the etiology of calcific aortic valve stenosis Journal of the American College of Cardiology. ,vol. 51, pp. 1327- 1336 ,(2008) , 10.1016/J.JACC.2007.12.031
Jens J Kaden, Christian F Vahl, Martin Borggrefe, Siegfried Hagl, Svetlana Bickelhaupt, Carl-Erik Dempfle, Rainer Grobholz, Karl K Haase, Martina Brueckmann, Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosis. Journal of Heart Valve Disease. ,vol. 13, pp. 560- 566 ,(2004)
B.Fendley Stewart, David Siscovick, Bonnie K. Lind, Julius M. Gardin, John S. Gottdiener, Vivienne E. Smith, Dalane W. Kitzman, Catherine M. Otto, Clinical Factors Associated With Calcific Aortic Valve Disease Journal of the American College of Cardiology. ,vol. 29, pp. 630- 634 ,(1997) , 10.1016/S0735-1097(96)00563-3
D Busseuil, Y Shi, M Mecteau, G Brand, A-E Kernaleguen, E Thorin, J-G Latour, E Rhéaume, J-C Tardif, Regression of aortic valve stenosis by ApoA-I mimetic peptide infusions in rabbits. British Journal of Pharmacology. ,vol. 154, pp. 765- 773 ,(2009) , 10.1038/BJP.2008.122
Elena Aikawa, Masanori Aikawa, Peter Libby, Jose-Luiz Figueiredo, Gabriel Rusanescu, Yoshiko Iwamoto, Daiju Fukuda, Rainer H. Kohler, Guo-Ping Shi, Farouc A. Jaffer, Ralph Weissleder, Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease Circulation. ,vol. 119, pp. 1785- 1794 ,(2009) , 10.1161/CIRCULATIONAHA.108.827972
Nancy Côté, Philippe Pibarot, Andrée Pépin, Dominique Fournier, Audrey Audet, Benoît Arsenault, Christian Couture, Paul Poirier, Jean-Pierre Després, Patrick Mathieu, Oxidized low-density lipoprotein, angiotensin II and increased waist cirumference are associated with valve inflammation in prehypertensive patients with aortic stenosis International Journal of Cardiology. ,vol. 145, pp. 444- 449 ,(2010) , 10.1016/J.IJCARD.2009.05.054
Xiaoping Yang, David A. Fullerton, Xin Su, Lihua Ao, Joseph C. Cleveland, Xianzhong Meng, Pro-Osteogenic Phenotype of Human Aortic Valve Interstitial Cells Is Associated With Higher Levels of Toll-Like Receptors 2 and 4 and Enhanced Expression of Bone Morphogenetic Protein 2 Journal of the American College of Cardiology. ,vol. 53, pp. 491- 500 ,(2009) , 10.1016/J.JACC.2008.09.052
Margareta Olsson, Mårten Rosenqvist, Jan Nilsson, Expression of HLA-DR antigen and smooth muscle cell differentiation markers by valvular fibroblasts in degenerative aortic stenosis Journal of the American College of Cardiology. ,vol. 24, pp. 1664- 1671 ,(1994) , 10.1016/0735-1097(94)90172-4
Alan Zajarias, Alain G. Cribier, Outcomes and Safety of Percutaneous Aortic Valve Replacement Journal of the American College of Cardiology. ,vol. 53, pp. 1829- 1836 ,(2009) , 10.1016/J.JACC.2008.11.059