High Pulmonary Levels of IL-6 and IL-1β in Children with Chronic Suppurative Lung Disease Are Associated with Low Systemic IFN-γ Production in Response to Non-Typeable Haemophilus influenzae

摘要: Non-typeable Haemophilus influenzae (NTHi) is commonly associated with chronic suppurative lung disease in children. We have previously shown that children a reduced capacity to produce IFN-γ response NTHi compared healthy control The aim of this study was determine if deficient NTHi-specific production heightened systemic or airway inflammation. measured panel cytokines (IFN-γ, IL-1β, IL-6, IL-8, IL-12 p70), antimicrobial proteins (LL-37, IP-10) as well cellular and clinical factors inflammation 70 disease. peripheral blood mononuclear cells challenged vitro live NTHi. Regression analysis used assess the association between IFN-γ. On multivariate regression, significantly negatively BAL concentrations inflammatory IL-6 (β=-0.316; 95%CI -0.49, -0.14; p=0.001) IL-1β (β=-0.023; -0.04, -0.01; p=0.001). This independent bacterial viral infection, cellularity severity bronchiectasis (using modified Bhalla score on chest CT scans). found limited evidence In summary, increased local poorer cell-mediated immune These data support emerging body impaired responses dysregulated may be linked contribute pathobiology