Estrogen replacement therapy and worsening of radiographic knee osteoarthritis: The Framingham study

摘要: Objective To examine whether estrogen replacement therapy (ERT) prevents worsening of radiographic knee osteoarthritis (OA) in elderly women. Methods A total 551 women ages 63-91 years (mean age 71) the Framingham Study were followed up from biennial examination 18 (1983-1985) to 22 (1992-1993). Data on postmenopausal ERT obtained every 2 years. Subjects classified into 3 groups according their use at 18: never users (n = 349), past 162), and current 40). Women received anteroposterior weight-bearing radiographs examinations 22. Using Kellgren Lawrence criteria, global OA was assessed, (grade range 0-4) individual features, such as osteophytes joint space narrowing, scored 0 3. Worsening defined either development that not present baseline (incident OA) or progression by ≥1 grade (progressive OA). Potential confounding factors included age, body mass index, weight change, smoking, injury, physical activity level, bone mineral density femoral neck. Results During 8 followup, 17.4% scores worsened 1 5.8% grades among ERT. Among users, only 11.7% none more than grade. After adjusting for other potential factors, relative risk incident comparison with 0.8 (95% confidence interval [95% CI] 0.5-1.4) 0.4 CI 0.1-3.0) users. Current also showed a trend toward decreased progressive compared (odds ratio [OR] 0.5, 95% 0.1-2.9). When both cases combined, had 60% (OR 0.4, 0.1-1.5). Conclusion This is first prospective cohort study effects OA. The results indicate moderate, but statistically significant, protective effect against white women. These findings corroborate those cross-sectional studies point further benefit female hormones