Mitochondrial permeability transition-pore inhibition enhances functional recovery after long-time hypothermic heart preservation.
作者： Katare Gopalrao Rajesh , Shiro Sasaguri , Suzuki Ryoko , Hironori Maeda , None
DOI: 10.1097/01.TP.0000085660.93090.79
关键词: Hypothermia 、 Transplantation 、 Circulatory system 、 Permeability (electromagnetism) 、 Mitochondrial permeability transition pore 、 Biophysics 、 Cardiovascular physiology 、 Heart preservation 、 Medicine 、 Biochemistry 、 Mitochondrion
摘要: Objectives.Long-time preservation of the donor heart before transplantation is associated with mitochondrial damages resulting in functional deterioration after transplantation, although exact mechanism behind this still uncertain. Here, we have demonstrated opening a nonspecific pore
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