Discrimination of tuberculous from carcinomatous pleural effusion by biochemical markers: adenosine deaminase, lysozyme, fibronectin and carcinoembryonic antigen.

摘要: We measured adenosine deaminase (ADA), lysozyme, fibronectin and carcinoembryonic antigen (CEA) in the pleural fluid of tuberculous carcinomatous effusion order to discriminate these two groups. Tuberculous had significantly higher levels ADA lysozyme than did effusion. When activity more 33 IU/ι is considered, diagnostic tests effusions showed a sensitivity 100%, specificity 95% accuracy 96%. A fluid/serum ratio (pl-ADA/s-ADA) above 1.1 was found 100% 53% (sensitivity 47%, 70%). level 12 μg/ml, selected as discriminating limit, 17% 83%, 88%). Pleural (PL/SL) also valuable discrimination cut-off 1.2 88% 93%, respectively. The mean concentration with that effusion, but there marked overlap between On other hand, CEA effusions. At 5 ng/ml, patients elevated levels, while none 53%, 65%). combined assay ADA, pl-ADA/s-ADA, PL/SL provide information differential diagnosis can not be considered have definite value.