The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo.
作者： Renee Risingsong , Gordon W. Gribble , Julie B. Stimmel , Timothy M. Willson , Evan Rosen
DOI:
关键词: U937 cell 、 Peroxisome proliferator-activated receptor 、 In vivo 、 In vitro 、 Biology 、 Cellular differentiation 、 Oleanolic acid 、 Transactivation 、 Cancer research 、 Biochemistry 、 Cell growth
摘要: Cyano-3, 12-dioxooleana-1, 9 (11)-dien-28-oyl] imidazole (CDDO-Im) is a novel synthetic triterpenoid more potent than its parent compound, 2-cyano-3, 12-dioxooleana-1, 9 (11)-dien-28-oic acid (CDDO), both in vitro and in vivo. CDDO-Im is highly active in suppressing cellular proliferation of human leukemia and breast cancer cell lines (IC50,∼ 10–30 nm). In U937 leukemia cells, CDDO-Im also induces monocytic differentiation as measured by increased cell surface expression of CD11b and CD36. In each of these assays, CDDO-Im is …
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