4-Hydroxynonenal Inhibits Interleukin-1βConverting Enzyme
作者： DARREN W. DAVIS , RAYMOND F. HAMILTON , ANDRIJ HOLIAN
关键词: Biochemistry 、 Reactive oxygen species 、 Lipid peroxidation 、 Interleukin 、 Chemistry 、 Lipopolysaccharide 、 Oxidative stress 、 4-Hydroxynonenal 、 Intracellular 、 Cysteine protease
摘要: Lipid peroxidation results from the interaction of reactive oxygen species and polyunsaturated fatty acids. Metabolites generated oxidative stress play an important role in pathogenesis a variety diseases biologic processes. One such product lipid is 4-hydroxynonenal (HNE). HNE thiol exhibits numerous cellular effects. In this study, inhibition cysteine protease, interleukin-1β (IL-1β) converting enzyme (ICE), by human blood mononuclear cells was investigated. blocked release lipopolysaccharide (LPS)-stimulated IL-1β (EC50 5 μM) IL-10 2 dose-dependent manner and, to lesser extent, tumor necrosis factor-α (TNF-α) 15 release. However, LPS-stimulated elevation intracellular proIL-1β levels not affected treatment. inhibited ICE activity lysed similar manner, measured hydrolysis fluorogenic substrate YVAD-AMC recombinant proIL-1β...
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