Biomechanical relationships between the corneal endothelium and Descemet's membrane.

摘要: The posterior face of the cornea consists corneal endothelium, a monolayer cuboidal cells that secrete and attach to Descemet's membrane, an exaggerated basement membrane. Dysfunction endothelium compromises barrier pump functions this layer maintain deturgesence. A large number endothelial dystrophies feature irregularities in suggesting create respond biophysical signals offered by their underlying matrix. This review provides overview bidirectional relationship between membrane endothelium. Several experimental methods have characterized richly topographic compliant microenvironment presented surface as well ultrastructure composition it builds during lifetime. We highlight signaling pathways involved mechanotransduction cues influence cell behavior. present specific example Fuchs' dystrophy condition which dysregulated may progression disease. Finally, we discuss some disease models regenerative strategies facilitate improved treatments for dystrophies.