Differential subtypes of diabetic older adults diagnosed with Alzheimer's disease

摘要: Aim The clinical management of diabetic elderly patients with Alzheimer's disease (AD) is hindered by several difficulties. The present study aimed to clarify the characteristics and pathophysiological properties AD in older adults. Methods A total 91 type 2 diabetes mellitus 161 non-diabetic individuals who were diagnosed recruited. Diabetic classified into two groups glycated hemoglobin (HbA1c) <7.0% or ≥7.0%. demographics, cognition, daily-life function, metabolic changes, treatment, behavioral psychological symptoms dementia (BPSD), as well brain pathophysiology, compared among three groups. Results Patients higher HbA1c had increased vascular complications impaired activities daily living decreased levels serum high-molecular-weight adiponectin 25-hydroxyvitamin D. Although cognitive status was similar groups, BPSD, including apathy, overeating excessive daytime sleeping appeared be frequency apolipoprotein E4 carriers posterior cerebral hypoperfusion (AD-pattern) on single-photon emission computed tomography poorly controlled subjects that patients, whereas included fewer an pattern tomography. Conclusion Subtypes identified based features pathophysiology. Physical are prevalent HbA1c. It seems likely difficulties due not only non-adherence but also dementia. Geriatr Gerontol Int 2014; 14 (Suppl. 2): 62–70.