Cerebrospinal fluid profile in frontotemporal dementia and Alzheimer's disease
作者： Murray Grossman , Jennifer Farmer , Susan Leight , Melissa Work , Peachie Moore
DOI: 10.1002/ANA.20477
关键词: Alzheimer's disease 、 Frontotemporal dementia 、 Cerebrospinal fluid 、 Frontal lobe 、 Pathology 、 Central nervous system disease 、 Temporal cortical atrophy 、 Degenerative disease 、 Psychology 、 Atrophy
摘要: We assessed cerebrospinal fluid (CSF) levels of tau and other biomarkers neurodegenerative disease. CSF vary widely in reports frontotemporal dementia (FTD). samples were assayed for tau, amyloid beta1-42 (A1-42), the isoprostane 8,12-iso-iPF2a-VI (iP) prospectively 64 patients with FTD, retrospectively 26 autopsied cases FTD or Alzheimer's disease (AD), 13 healthy seniors. To validate our observations vivo, we correlated cortical atrophy 17 using voxel-based morphometry analyses high-resolution magnetic resonance imaging. Abeta1-42, iP differed significantly compared AD. Individual patient showed that 34% FD had low although this was never seen A discriminant analysis based on able to classify 88.5% these a manner corresponds their clinical autopsy diagnosis. Magnetic imaging studies correlate right frontal left temporal atrophy, brain regions known be atrophic autopsy-proved FTD. conclude are reduced many
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