Menadione is a metabolite of oral vitamin K.

作者: Leon J. Schurgers , Martin J. Shearer , Henk H. W. Thijssen , Lily M. T. Vervoort

DOI: 10.1079/BJN20051630

关键词: EndocrinologyOral administrationChemistryExcretionUrineMenadioneIntestinal absorptionMetaboliteInternal medicineMetabolismRetinol

摘要: … Phylloquinone is converted into menaquinone-4 and accumulates in extrahepatic tissues. … of menadione in urine and the effect of vitamin K intake on its excretion. Menadione in urine …

参考文章(30)
J Nathan Hagstrom, Edwin G Bovill, Roger F Soll, Kenneth W Davidson, James A Sadowski, The pharmacokinetics and lipoprotein fraction distribution of intramuscular vs. oral vitamin K1 supplementation in women of childbearing age: effects on hemostasis. Thrombosis and Haemostasis. ,vol. 74, pp. 1486- 1490 ,(1995) , 10.1055/S-0038-1649970
Raymond Losito, Charles A. Owen, Eunice V. Flock, Metabolism of [14C]menadione. Biochemistry. ,vol. 6, pp. 62- 68 ,(1967) , 10.1021/BI00853A012
Stein K, Conly Jm, The production of menaquinones (vitamin K2) by intestinal bacteria and their role in maintaining coagulation homeostasis. Progress of Food and Nutrition Science. ,vol. 16, pp. 307- 343 ,(1992)
Marilyn D. Resh, Membrane Targeting of Lipid Modified Signal Transduction Proteins Sub-cellular biochemistry. ,vol. 37, pp. 217- 232 ,(2004) , 10.1007/978-1-4757-5806-1_6
Isuke Imada, Masazumi Watanabe, Norichika Matsumoto, Hiroshi Morimoto, Metabolism of ubiquinone-7. Biochemistry. ,vol. 9, pp. 2870- 2878 ,(1970) , 10.1021/BI00816A018
M.J. Shearer, A. Mcburney, P. Barkhan, Studies on the Absorption and Metabolism of Phylloquinone (Vitamin K1) in Man Vitamins and Hormones Series. ,vol. 32, pp. 513- 542 ,(1975) , 10.1016/S0083-6729(08)60025-4
Martin Kohlmeier, Andreas Salomon, Jörg Saupe, Martin J. Shearer, Transport of vitamin K to bone in humans. Journal of Nutrition. ,vol. 126, ,(1996) , 10.1093/JN/126.SUPPL_4.1192S
Isabelle Carrié, Jacques Portoukalian, Raffaela Vicaretti, Joseph Rochford, Stéphanie Potvin, Guylaine Ferland, Menaquinone-4 Concentration Is Correlated with Sphingolipid Concentrations in Rat Brain Journal of Nutrition. ,vol. 134, pp. 167- 172 ,(2004) , 10.1093/JN/134.1.167
S Lamon-Fava, J A Sadowski, K W Davidson, M E O’Brien, J R McNamara, E J Schaefer, Plasma lipoproteins as carriers of phylloquinone (vitamin K1) in humans. The American Journal of Clinical Nutrition. ,vol. 67, pp. 1226- 1231 ,(1998) , 10.1093/AJCN/67.6.1226
Robert T. Davidson, Andrea L. Foley, Jean A. Engelke, John W. Suttie, Conversion of dietary phylloquinone to tissue menaquinone-4 in rats is not dependent on gut bacteria Journal of Nutrition. ,vol. 128, pp. 220- 223 ,(1998) , 10.1093/JN/128.2.220