Uncovering the antitumor effects and mechanisms of Shikonin against colon cancer on comprehensive analysis

作者: Yang Chen , Leting Si , Jinghui Zhang , Hengyuan Yu , Xuesong Liu

DOI: 10.1016/J.PHYMED.2021.153460

关键词: Cancer researchCell cycleTranscriptomePyrimidine metabolismViability assayChemistryColorectal cancerArginineCytotoxic T cellApoptosis

摘要: … In this work, cell viability, cell cycle and cell apoptosis in human colon cancer cells were assessed … in purine metabolism and arginine biosynthesis were further determined by RT-qPCR. …

参考文章(22)
M. del Ara Rangel, R. A. González-Polo, A. Caro, E. del Amo, L. Palomo, E. Hernández, G. Soler, J. M. Fuentes, Diagnostic performance of arginase activity in colorectal cancer. Clinical and Experimental Medicine. ,vol. 2, pp. 53- 57 ,(2002) , 10.1007/S102380200007
XP Guo, XY Zhang, SD Zhang, None, Clinical trial on the effects of shikonin mixture on later stage lung cancer Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine / Zhongguo Zhong xi yi jie he yan jiu hui (chou), Zhong yi yan jiu yuan, zhu ban. ,vol. 11, pp. 598- ,(1991)
Katja Dettmer, Pavel A. Aronov, Bruce D. Hammock, Mass spectrometry-based metabolomics. Mass Spectrometry Reviews. ,vol. 26, pp. 51- 78 ,(2007) , 10.1002/MAS.20108
Chiara Rampazzo, Cristina Miazzi, Elisa Franzolin, Giovanna Pontarin, Paola Ferraro, Miriam Frangini, Peter Reichard, Vera Bianchi, Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances. Mutation Research-genetic Toxicology and Environmental Mutagenesis. ,vol. 703, pp. 2- 10 ,(2010) , 10.1016/J.MRGENTOX.2010.06.002
Hsuan-Ying Huang, Wen-Ren Wu, Yu-Hui Wang, Jun-Wen Wang, Fu-Min Fang, Jen-Wei Tsai, Shau-Hsuan Li, Hsiao-Chin Hung, Shih-Chen Yu, Jui Lan, Yow-Ling Shiue, Chung-His Hsing, Li-Tzong Chen, Chien-Feng Li, ASS1 as a Novel Tumor Suppressor Gene in Myxofibrosarcomas: Aberrant Loss via Epigenetic DNA Methylation Confers Aggressive Phenotypes, Negative Prognostic Impact, and Therapeutic Relevance Clinical Cancer Research. ,vol. 19, pp. 2861- 2872 ,(2013) , 10.1158/1078-0432.CCR-12-2641
Wen Tan, Jinjian Lu, Mingqing Huang, Yingbo Li, Meiwan Chen, Guosheng Wu, Jian Gong, Zhangfeng Zhong, Zengtao Xu, Yuanye Dang, Jiajie Guo, Xiuping Chen, Yitao Wang, Anti-cancer natural products isolated from chinese medicinal herbs Chinese Medicine. ,vol. 6, pp. 27- 27 ,(2011) , 10.1186/1749-8546-6-27
Eisuke Kobayashi, Mari Masuda, Robert Nakayama, Hitoshi Ichikawa, Reiko Satow, Miki Shitashige, Kazufumi Honda, Umio Yamaguchi, Ayako Shoji, Naobumi Tochigi, Hideo Morioka, Yoshiaki Toyama, Setsuo Hirohashi, Akira Kawai, Tesshi Yamada, Reduced Argininosuccinate Synthetase Is a Predictive Biomarker for the Development of Pulmonary Metastasis in Patients with Osteosarcoma Molecular Cancer Therapeutics. ,vol. 9, pp. 535- 544 ,(2010) , 10.1158/1535-7163.MCT-09-0774
Yunfei Zhou, Federico Tozzi, Jinyu Chen, Fan Fan, Ling Xia, Jinrong Wang, Guang Gao, Aijun Zhang, Xuefeng Xia, Heather Brasher, William Widger, Lee M. Ellis, Zhang Weihua, Intracellular ATP Levels Are a Pivotal Determinant of Chemoresistance in Colon Cancer Cells Cancer Research. ,vol. 72, pp. 304- 314 ,(2012) , 10.1158/0008-5472.CAN-11-1674
Yanrong Qian, Xuan Wang, Yunsheng Li, Yanyang Cao, Xiaozhuo Chen, Extracellular ATP a New Player in Cancer Metabolism: NSCLC Cells Internalize ATP In Vitro and In Vivo Using Multiple Endocytic Mechanisms Molecular Cancer Research. ,vol. 14, pp. 1087- 1096 ,(2016) , 10.1158/1541-7786.MCR-16-0118
Yan Long, Wen-Bin Tsai, Dajuan Wang, David H. Hawke, Niramol Savaraj, Lynn G. Feun, Mien-Chie Hung, Helen H.W. Chen, Macus Tien Kuo, Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy. Cancer Letters. ,vol. 388, pp. 54- 63 ,(2017) , 10.1016/J.CANLET.2016.11.028