Anesthetic toxic isoflurane and health risk assessment in the operation room in Abadan, Iran during 2018

作者: Arghavan Afra , Maziyar Mollaei Pardeh , Hamed Saki , Majid Farhadi , Sahar Geravandi

DOI: 10.1016/J.CEGH.2019.08.008

关键词: Indoor air qualityIsofluraneOperation roomSorbent tubeAnesthesiaShahidHealth risk assessmentMedicineVentilation (architecture)Anesthetic

摘要: Abstract Introduction Anesthetic gases are very important for health among care worker (HCWs) and patients in medical centers. Operating rooms (ORs) is the most ward that use anesthetic gases. Isoflurane dangerous HCWs. Objective In this study, we have associated concentration of toxic isoflurane (ppm) risk assessment due to exposure common Valiasr Shahid Beheshti teaching hospital operating room during 2018. Methods used active sampling system by portable pump SKC tubes (sorbent Tube Tenax TA 250 mg) detection (ppm). Different points were selected sampling. Hazard index (HI) quantified calculating non-cancer causing Results According result had lowest highest level isoflurane. Based on indoor air quality operation 2.129 2.436 ppm, respectively. results from current hazard was under 1.0 it amount showed no significant adverse endpoint attributed Conclusion Result study average 2018 because flaw ventilation significantly higher than standard.

参考文章(43)
Pavle M. Joksovic, Nadia Lunardi, Vesna Jevtovic-Todorovic, Slobodan M. Todorovic, Early Exposure to General Anesthesia with Isoflurane Downregulates Inhibitory Synaptic Neurotransmission in the Rat Thalamus Molecular Neurobiology. ,vol. 52, pp. 952- 958 ,(2015) , 10.1007/S12035-015-9247-6
Elena G. Dascalaki, Argyro Lagoudi, Constantinos A. Balaras, Athina G. Gaglia, Air quality in hospital operating rooms Building and Environment. ,vol. 43, pp. 1945- 1952 ,(2008) , 10.1016/J.BUILDENV.2007.11.015
Christian Byhahn, Hans-Joachim Wilke, Klaus Westphal, Occupational exposure to volatile anaesthetics: epidemiology and approaches to reducing the problem CNS Drugs. ,vol. 15, pp. 197- 215 ,(2001) , 10.2165/00023210-200115030-00004
A Bargellini, S Rovesti, A Barbieri, R Vivoli, R Roncaglia, E Righi, P Borella, Effects of chronic exposure to anaesthetic gases on some immune parameters. Science of The Total Environment. ,vol. 270, pp. 149- 156 ,(2001) , 10.1016/S0048-9697(00)00778-6
Alex Macario, Matthew Weinger, Stacie Carney, Ann Kim, Which Clinical Anesthesia Outcomes Are Important to Avoid? The Perspective of Patients Anesthesia & Analgesia. ,vol. 89, pp. 652- 658 ,(1999) , 10.1097/00000539-199909000-00022
Burkhard Gustorff, Norbert Lorenzl, Laleh Aram, Claus G. Krenn, Brigitte P. Jobst, Klaus H. Hoerauf, Environmental monitoring of sevoflurane and nitrous oxide using the cuffed oropharyngeal airway. Anesthesia & Analgesia. ,vol. 94, pp. 1244- 1248 ,(2002) , 10.1097/00000539-200205000-00036
N. Raj, K. A. Henderson, J. E. Hall, I. M. Aguilera, M. Harmer, A. Hutchings, B. Williams, Evaluation of personal, environmental and biological exposure of paediatric anaesthetists to nitrous oxide and sevoflurane* Anaesthesia. ,vol. 58, pp. 630- 636 ,(2003) , 10.1046/J.1365-2044.2003.03235.X