PROSTATIC LEVELS OF FATTY ACIDS AND THE HISTOPATHOLOGY OF LOCALIZED PROSTATE CANCER
作者： VINCENT L. FREEMAN , MOHSEN MEYDANI , SHERRI YONG , JOSEPH PYLE , ROBERT C. FLANIGAN
DOI: 10.1016/S0022-5347(05)66991-1
关键词: Prostate cancer 、 Histopathology 、 Risk factor 、 Prostatectomy 、 Pathology 、 Surgical margin 、 Prostate 、 Perineural invasion 、 Urology 、 Tumor progression 、 Medicine
摘要: Purpose: The consumption of various fatty acids has been associated with advanced stage and fatal prostate cancer. While numerous mechanisms have postulated, to our knowledge there physiological data linking exposure prognosis in humans are lacking. We examined prostatic levels individual relation the prevalence histopathological characteristics invasiveness risk progression 49 men undergoing radical prostatectomy for localized cancer.Materials Methods: Fatty were measured using capillary gas chromatography fresh nonmalignant tissue collected at surgery. Markers increased (Gleason sum 7 or greater, perineural invasion, anatomical surgical margin involvement, extracapsular extension, seminal vesical involvement T3 tumor) evaluated separately. Each marker was dichotomized into a yes (case) no (control) level patients grouped accordingly. Mean concen...
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