The oncogenicity of jun.

摘要: The oncogenic transforming potential of the jun oncogene was investigated with viral constructs that contain various terminal deletions v-jun, c-jun and recombinants between cellular genes. Cellular can induce transformation chicken embryo fibroblasts a low efficiency. High efficiency is dependent on alterations in major transactivator domain. A deletion lacks domain non-transforming. These observations are compatible conclusion transcriptional regulation plays an important part oncogenesis. In cells transformed by expressing high levels expression not constitutively upregulated. may therefore contribute to these cells.