Gene Therapy Approaches in an Autoimmune Demyelinating Disease: Multiple Sclerosis.

摘要: Multiple Sclerosis (MS) is the most common autoimmune demyelinating disease of Central Nervous System (CNS). It a multifactorial which develops in an immune-mediated way under influences both genetic and environmental factors. Demyelination observed brain spinal cord leading to neuro-axonal damage patients with MS. Due infiltration different immune cells such as T-cells, B-cells, monocytes macrophages, focal lesions are Currently available medications treating MS mainly based on two strategies; i) ease specific symptoms or ii) reduce progression. However, these tend induce adverse effects limited therapeutic efficacy due protective function blood-brain barrier. Therefore, researchers have been working for last four decades discover better solutions by introducing gene therapy approaches generally following three strategies, prevention symptoms, halt reverse progression iii) heal CNS promoting remyelination axonal repair. In decades, there some remarkable successes experimental mice model - encephalomyelitis (EAE) suggests that it not far would start human subjects ensuring highest levels safety efficacy. this review, we summarised attempted animal models towards