Autotaxin and Breast Cancer: Towards Overcoming Treatment Barriers and Sequelae
作者： Matthew G. K. Benesch , Xiaoyun Tang , David N. Brindley
关键词: Metastasis 、 Lysophosphatidic acid 、 Internal medicine 、 Idiopathic pulmonary fibrosis 、 Medicine 、 Oncology 、 Autotaxin 、 Tumor microenvironment 、 Breast cancer 、 Radiation therapy 、 Adverse effect
摘要: After a decade of intense preclinical investigations, the first in-class autotaxin inhibitor, GLPG1690, has entered Phase III clinical trials for idiopathic pulmonary fibrosis. In intervening time, deeper understanding role autotaxin–lysophosphatidate (LPA)–lipid phosphate phosphatase axis in breast cancer progression and treatment resistance emerged. Concordantly, appreciation tumor microenvironment chronic inflammation biology matured. The LPA as central mediator behind these concepts been exemplified within field. this review, we will summarize current challenges therapy delineate how blocking signaling could provide novel adjuvant therapeutic options overcoming adverse side effects, including radiation-induced advent inhibitors practice herald their applications therapies to improve indexes existing treatments other cancers.
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