ENZYMOLOGY: Nickel to the Fore
作者： R. K. Thauer
关键词: Active site 、 Crystal structure 、 Crystallography 、 Carbon monoxide 、 Chemistry 、 Metallurgy 、 Nickel 、 Multidisciplinary
摘要: Nickel was long thought not to be important in biology, but now several enzymes are known depend on nickel for activity. In his Perspective, [Thauer][1] highlights the report by [ Dobbek et al .][2], whose high-resolution crystal structure of a enzyme reveals novel cluster active site. The offers surprising insights into site and likely mechanism through which harvests electrons from carbon monoxide. [1]: http://www.sciencemag.org/cgi/content/full/293/5533/1264 [2]: http://www.sciencemag.org/cgi/content/short/293/5533/1281
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