Outcomes in a Multi-institutional Cohort of Patients Treated With Intraoperative Radiation Therapy for Advanced or Recurrent Renal Cell Carcinoma

摘要: Purpose/Objective(s) This study aimed to analyze outcomes in a multi-institutional cohort of patients with advanced or recurrent renal cell carcinoma (RCC) who were treated intraoperative radiation therapy (IORT). Methods and Materials Between 1985 2010, 98 received IORT for locally RCC at 9 institutions. The median follow-up time surviving was 3.5 years. Overall survival (OS), disease-specific (DSS), disease-free (DFS) estimated the Kaplan-Meier method. Chained imputation accounted missing data, multivariate Cox hazards regression tested significance. Results delivered during nephrectomy disease (28%) resection fossa (72%). Sixty-nine percent male, age 58 At primary resection, T stages as follows: 17% T1, 12% T2, 55% T3, 16% T4. Eighty-seven had visibly complete tumor. Preoperative postoperative external beam administered 27% 35% patients, respectively. 5-year OS 37% disease. respective DSS 41% 60%. DFS 39% 52%. Initial nodal involvement (hazard ratio [HR] 2.9-3.6, P =.03). For tumors, positive margin status (HR 2.6, =.01) associated decreased OS. Conclusions We report largest known managed by have identified several factors survival. receiving setting local recurrence compare favorably similar cohorts alone suggesting potential improved IORT.