A Physiological Role of Epidermal Growth Factor in Male Reproductive Function
作者： O Tsutsumi , H Kurachi , T Oka
关键词: Internal medicine 、 Hormone 、 Sperm 、 Submandibular gland 、 Epididymis 、 Biology 、 Epidermal growth factor 、 Testosterone 、 Spermatogenesis 、 Ratón 、 Endocrinology
摘要: Epidermal growth factor (EGF) stimulates the proliferation of various mammalian cells in culture, but its physiological role is not well defined. In mature male mice, large amounts of EGF are produced in the submandibular gland; it is present in the circulation at approximately 5 nanograms of EGF per milliliter of plasma. Sialoadenectomy (removal of the submandibular glands) decreased the amount of circulating EGF to an undetectable level but did not affect the circulating levels of testosterone or follicle-stimulating hormone. The …
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