Fungal Appendicitis in Immunocompromised Children. Indications and Contraindications for Laparoscopic Appendectomy: A Report on 2 Successful Cases.

作者: Veronica Carlini , Valeria Calcaterra , Nunzia Decembrino , Laura Rubert , Noemi Pasqua

DOI: 10.1097/MPH.0000000000000563

关键词: AntifungalOverall survivalMedicineAppendicitisGeneral surgeryIncreased riskLaparoscopyLaparoscopic surgerySurgeryGold standard

摘要: In leukemic patients, appendectomy must be approached with caution because of the increased risk complications. Fungal appendicitis is rare and only a few cases have been described in literature, particularly immunocompromised individuals whom this infection can fatal. We present 2 pediatric patients acute myeloid leukemia, who developed during postchemotherapy neutropenic phase, while receiving antifungal prophylaxis. Fever was first sign infection. Laparoscopic performed without postoperative The histologic examination culture analysis showed presence fungal elements; systemic also excluded. children signs peritoneal irritation are not always obvious. histopathologic demonstration elements tissue reaction mandatory for definitive diagnosis. should considered as gold standard procedure to avoid dissemination. Moreover, laparoscopic surgery its inherent mini-invasive surgical advantages may improve overall survival incurring significant

参考文章(24)
Wisam Khoury, Oded Szold, Dror Soffer, Yehuda Kariv, Ruth Wasserlauf, Joseph M. Klausner, Daniel Ogorek, Avi A. Weinbroum, Prophylactic fluconazole does not improve outcome in patients with purulent and fecal peritonitis due to lower gastrointestinal perforation. American Surgeon. ,vol. 76, pp. 197- 202 ,(2010) , 10.1177/000313481007600215
Jiří Manych, Aspergillosis Infectious Disease Clinics of North America. ,vol. 16, pp. 875- 894 ,(2002) , 10.1016/S0891-5520(02)00035-1
Ioannis Koutsounas, Emmanouil Pyleris, Isolated enteric aspergillosis in a non severely immunocompromised patient. Case report and literature review. Arab Journal of Gastroenterology. ,vol. 16, pp. 72- 75 ,(2015) , 10.1016/J.AJG.2015.06.008
Laura W. Lamps, Infectious causes of appendicitis. Infectious Disease Clinics of North America. ,vol. 24, pp. 995- 1018 ,(2010) , 10.1016/J.IDC.2010.07.012
Jarod P. McAteer, Sabrina E. Sanchez, Joe C. Rutledge, John H. T. Waldhausen, Isolated appendiceal typhlitis masquerading as perforated appendicitis in the setting of acute lymphoblastic leukemia Pediatric Surgery International. ,vol. 30, pp. 561- 564 ,(2014) , 10.1007/S00383-014-3473-2
Michael J. Hobson, David E. Carney, Kimberly A. Molik, Terry Vik, L.R. “Tres” Scherer, Thomas M. Rouse, Karen W. West, Jay L. Grosfeld, Deborah F. Billmire, Appendicitis in childhood hematologic malignancies: analysis and comparison with typhilitis. Journal of Pediatric Surgery. ,vol. 40, pp. 214- 220 ,(2005) , 10.1016/J.JPEDSURG.2004.09.048
T. Bömelburg, N. Roos, H. -J. von Lengerke, J. Ritter, Invasive aspergillosis complicating induction chemotherapy of childhood leukaemia European Journal of Pediatrics. ,vol. 151, pp. 485- 487 ,(1992) , 10.1007/BF01957749
Carlos A Angel, Bhaskar N Rao, Earle Wrenn Jr, Thom E Lobe, AP Mahesh Kumar, None, Acute appendicitis in children with leukemia and other malignancies: Still a diagnostic dilemma Journal of Pediatric Surgery. ,vol. 27, pp. 476- 479 ,(1992) , 10.1016/0022-3468(92)90342-5
Philip R. Exelby, Amir Ghandchi, Nicolas Lansigan, Ira Schwartz, Management of the acute abdomen in children with leukemia Cancer. ,vol. 35, pp. 826- 829 ,(1975) , 10.1002/1097-0142(197503)35:3<826::AID-CNCR2820350339>3.0.CO;2-B
Thomas Lehrnbecher, Martina Becker, Dirk Schwabe, Ulrike K??hl, Susanne Kriener, Klaus-Peter Hunfeld, Helga Schmidt, Peter Beyer, Thomas Klingebiel, Peter Bader, Jan S??rensen, Primary intestinal aspergillosis after high-dose chemotherapy and autologous stem cell rescue. Pediatric Infectious Disease Journal. ,vol. 25, pp. 465- 466 ,(2006) , 10.1097/01.INF.0000217475.83393.F6