Cholestasis in the Hospitalized Patient

摘要: Cholestasis results from the accumulation of bile acids within liver, ultimately leading to hepatotoxicity. There are multiple causes cholestasis in hospitalized patient, and this chapter focuses on hematopoietic stem cell transplant (HSCT) recipient. jaundice common setting HSCT. The differential is broad includes extrahepatic biliary obstruction, preexisting liver disease, sepsis, hemolysis, parenteral nutrition, drug-induced injury, graft-versus-host disease (GVHD), sinusoidal obstruction syndrome. Additionally, may be multifactorial etiology. Understanding risks timing cholestatic injury crucial its diagnosis. Preventive measures help minimize injury; however, specific treatments lacking.