Synaptotoxicity in Alzheimer's disease involved a dysregulation of actin cytoskeleton dynamics through cofilin 1 phosphorylation
作者： Travis Rush , Jose Martinez-Hernandez , Marc Dollmeyer , Marie Lise Frandemiche , Eve Borel
DOI: 10.1523/JNEUROSCI.1409-18.2018
关键词: Postsynaptic density 、 Cell biology 、 Cofilin 1 、 Excitatory postsynaptic potential 、 Rho-associated protein kinase 、 Cofilin 、 Dendritic spine 、 Actin cytoskeleton 、 Postsynaptic potential 、 Chemistry
摘要: … Cofilin-actin rods are observed in neurons exposed to Aβ oligomers (Aβo) and in tissue from AD patients, and others have described an increased cofilin … formation of cofilin-actin rods. …
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