Alterations in human natural killer cell activity and monocyte cytotoxicity induced by zinc deficiency.

摘要: Zinc deficiency alters lymphocyte and monocyte function in man animals. A patient with isolated zinc was found to have lymphopenia (420 lymphocytes/microliter), depressed T-cell mitogen response (48% of normal control), increased numbers circulating T-suppressor cells (OKT8 reactive cells) decreased T-helper (OKT4 cells). Activity the patient's natural killer (NK) 1 lytic unit/10(6) (normal 10 40), cytotoxicity (MC) four times that controls. repletion vivo improved peripheral count, corrected abnormal OKT8-to-OKT4 ratio, normalized mitogen, NK function, lowered MC control values. divalent cation chelator, 1,10-orthophenanthroline (OP), used simulate vitro. T-cells exposed OP are nonresponsive unless is added. lymphocytes from donors a time- dose-dependent manner. activity blood (PBL) 12 50 microM for 16 hr 10.3 +/- 7 units/10(6) (mean S.E.M.) vs. 32.6 14 incubated medium alone. When monocytes were OP, however, significantly range two five control. OP-induced alterations reversed by addition but not calcium or magnesium. Since thought be important host tumor immunity, metabolism may implications human immune surveillance mechanisms.