Dehydroepiandrosterone Sulfate (DHEAS) Stimulates the First Step in the Biosynthesis of Steroid Hormones
作者： Jens Neunzig , Rita Bernhardt
DOI: 10.1371/JOURNAL.PONE.0089727
关键词: Adrenodoxin 、 Cholesterol side-chain cleavage enzyme 、 Pregnenolone 、 Adrenodoxin reductase 、 Steroid 、 Endocrinology 、 Biochemistry 、 Hormone 、 Internal medicine 、 Cholesterol 、 Dehydroepiandrosterone sulfate 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: Dehydroepiandrosterone sulfate (DHEAS) is the most abundant circulating steroid in human, with the highest concentrations between age 20 and 30, but displaying a significant decrease with age. Many beneficial functions are ascribed to DHEAS. Nevertheless, long-term studies are very scarce concerning the intake of DHEAS over several years, and molecular investigations on DHEAS action are missing so far. In this study, the role of DHEAS on the first and rate-limiting step of steroid hormone biosynthesis was analyzed in a …
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