Omega-3 fatty acid supplementation and reduction of traumatic axonal injury in a rodent head injury model
作者： James D Mills , Julian E Bailes , Cara L Sedney , Heather Hutchins , Barry Sears
关键词: Traumatic brain injury 、 Head injury 、 Eicosapentaenoic acid 、 Diffuse axonal injury 、 Rodent 、 Animal studies 、 Docosahexaenoic acid 、 Medicine 、 Physiology 、 Surgery 、 Fatty acid
摘要: Object Traumatic brain injury remains the most common cause of death in persons under 45 years age Western world. Recent evidence from animal studies suggests that supplementation with omega-3 fatty acid (O3FA) (particularly eicosapentaenoic [EPA] and docosahexaenoic [DHA]) improves functional outcomes following focal neural injury. The purpose this study is to determine benefits O3FA diffuse axonal rats. Methods Forty adult male Sprague-Dawley rats were used. Three groups 10 subjected an impact acceleration remaining group underwent a sham-injury procedure (surgery, but no injury). Two supplemented or 40 mg/kg/day O3FA; third injured served as unsupplemented control group. sham-injured likewise received supplementation. Serum levels determined isolated plasma phospholipids prior an...
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