Expression of HIV in lymph node cells of LAS patients. Immunohistology, in situ hybridization, and identification of target cells.

摘要: Monoclonal antibodies (MAb) anti-HIV core and envelope proteins in situ hybridization, using cDNA HIV probe, were employed to determine which lymph node cells LAS patients express viral antigens nucleic acids. The results have been correlated with the histologic phases of germinal center lysis detected DRC-1 MAb directed against follicular dendritic reticulum (FDRC). Viral occasionally on high endothelial paracortical venules frequently FDR accessory cells; this last finding correlates well extent FDRC CD4+ CD8+ lymphocyte infiltration centers. replication, by was observed mononucleated present T B areas and, one case, flat endothelium.