Immunosuppressive factors from adult T-cell leukemia cells.

摘要: Abstract The mechanism of immunodeficiency in adult T-cell leukemia (ATL) patients was studied vitro. Peripheral blood lymphocytes from ATL and cell lines such as Hut 102, MT 1, 2 were not activated to proliferate by the stimulation with concanavalin A suppressed normal lymphocyte proliferative responses induced when cultured together. sera culture supernatants cells also A. By Sephacryl S-200 column chromatography, suppressive factors fractionated a single peak molecular weights 50,000 70,000. unstable acid treatment but stable base, heat, freezing-thawing, trypsin. production interleukin T-cells responsiveness 2, expression receptors on 1 monocytes. These results suggest that immunosuppressive produced have some roles induction immunodeficient states patients.