Method of treatment of thyroid cancer

作者: James Fagin

DOI:

关键词: Cancer researchEpidermal growth factorThyroid cancerDiseaseRet geneMedicineImmunology

摘要: The present invention relates to a method of treating warm-blooded animal, especially human, having disease which is mediated or characterized by mutations in the RET gene, thyroid cancer, cancer harboring mutations, comprising administering said animal therapeutically effective amount compound decreases activity epidermal growth factor (EGF), as defined herein.

参考文章(17)
Alan B. Cooper, Viyyoor M. Girijavallabhan, Dinanath F. Rane, James J.-S. Wang, F. George Njoroge, Ronald J. Doll, Jagdish A. Desai, Hugh Y. Zhu, Novel farnesyl protein transferase inhibitors as antitumor agents ,(2004)
Rodney Caughren Schnur, Lee Daniel Arnold, Alkynl and azido-substituted 4-anilinoquinazolines ,(2008)
Peter Traxler, Elisabeth Buchdunger, Cheryl H. Baker, Rachel Tsan, Isaiah J. Fidler, Jerry J. Killion, Carmen C. Solorzano, Pamela Cohen, Optimization for the blockade of epidermal growth factor receptor signaling for therapy of human pancreatic carcinoma Clinical Cancer Research. ,vol. 7, pp. 2563- 2572 ,(2001)
Barbara Pasini, Isabella Ceccherini, Giovanni Romeo, RET mutations in human disease Trends in Genetics. ,vol. 12, pp. 138- 144 ,(1996) , 10.1016/0168-9525(96)10012-3
C Chandra Kumar, Vincent Madison, Drugs targeted against protein kinases. Expert Opinion on Emerging Drugs. ,vol. 6, pp. 303- 315 ,(2001) , 10.1517/14728214.6.2.303
Cinzia Lanzi, Giuliana Cassinelli, Tiziana Pensa, Marco Cassinis, Romolo A. Gambetta, Maria G. Borrello, Ernesto Menta, Marco A. Pierotti, Franco Zunino, Inhibition of transforming activity of the ret/ptc1 oncoprotein by a 2-indolinone derivative. International Journal of Cancer. ,vol. 85, pp. 384- 390 ,(2000) , 10.1002/(SICI)1097-0215(20000201)85:3<384::AID-IJC15>3.0.CO;2-Y
M. Taniguchi, Y. Uehara, M. Matsuyama, M. Takahashi, Inhibition of Ret Tyrosine Kinase Activity by Herbimycin A Biochemical and Biophysical Research Communications. ,vol. 195, pp. 208- 214 ,(1993) , 10.1006/BBRC.1993.2031
Peter Traxler, Guido Bold, Hans-Georg Capraro, Giorgio Caravatti, 4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives ,(2002)
Mary M. Bendig, Jose Saldanha, Catherine A. Kettleborough, Humanized and chimeric anti-epidermal growth factor receptor monoclonal antibodies ,(1992)