Identification and Characterization of Metabolically Benign Obesity in Humans

摘要: Background: Obesity represents a risk factor for insulin resistance, type 2 diabetes mellitus, and atherosclerosis. In addition, any given amount of total body fat, an excess visceral fat or accumulation in the liver skeletal muscle augments risk. Conversely, even obesity, metabolically benign distribution phenotype may exist. Methods: 314 subjects, we measured body, visceral, subcutaneous with magnetic resonance (MR) tomography proton MR spectroscopy. Insulin sensitivity was estimated from oral glucose tolerance test results. Subjects were divided into 4 groups: normal weight (body mass index [BMI] [calculated as kilograms by height meters squared], 25.0), overweight (BMI, 25.0-29.9), obese–insulin sensitive (IS) 30.0 placement upper quartile sensitivity), resistant (IR) lower 3 quartiles sensitivity). Results: Total higher obese groups compared normal-weight group (P.05); however, no differences observed between groups. contrast, ectopic (P.001) particularly (4.3%±0.6% vs 9.5%±0.8%)andtheintima-mediathicknessofthecommon carotidartery(0.54±0.02vs0.59±0.01mm)werelowerand (17.4±0.9 7.3±0.3 arbitrary units) obese-IS obese-IR (P.05). Unexpectedly, had almost identical intima-media thickness not statistically different (18.2±0.9 AU 0.51±0.02 mm, respectively). Conclusions: A obesity that is accompanied resistance early atherosclerosis exists humans. Furthermore, be more important than determination such beneficial obesity.