Intracranial pressure in the cat during nitroglycerin-induced hypotension.

摘要: Intracranial pressure measurements were made during nitroglycerin-induced hypotension in the cat anesthetized with halothane. A total of 48 individual observations eight animals. The administration sufficient nitroglycerin to decrease mean arterial from a control value 87 +/- 7 torr by 12 4 resulted an increase intracranial 2 torr. Larger decreases blood associated larger increases pressure. was similar that previously reported for nitroprusside, and greater as well more reproducible than trimethaphan. Thus, may produce significant pressure, this be limiting factor its clinical use.