Methods of Computational Interactomics for Investigating Interactions of Human Proteoforms.

摘要: Human genome contains ca. 20,000 protein-coding genes that could be translated into millions of unique protein species (proteoforms). Proteoforms coded by a. single gene often have different functions, which implies partners. By interacting with each other, proteoforms create network reflecting the dynamics cellular processes in an organism. Perturbations protein-protein interactions change topology, triggers pathological processes. Studying is relatively new research area proteomics, and this why there are comparatively few experimental studies on interaction proteoforms. Bioinformatics tools can facilitate such providing valuable complementary information to data and, particular, expanding possibilities proteoform interactions.