Noncytotoxic Lytic Granule-Mediated Maintenance of HSV-1 Neuronal Latency
作者： Jared Evan Knickelbein
DOI:
关键词: Cytotoxic T cell 、 Granzyme B 、 Ex vivo 、 Biology 、 Herpes simplex virus 、 In vivo 、 Virology 、 HSL and HSV 、 Immediate early protein 、 Lytic cycle
摘要: Reactivation of herpes simplex virus (HSV) from neuronal latency is a common and potentially devastating cause disease worldwide. CD8 T cells can completely inhibit HSV reactivation, IFN-gamma affords portion this protection. We now show that cell lytic granules are also required for the maintenance type 1 (HSV-1) both in vivo ex cultures, their directed release into junctions with neurons latently infected ganglia does not induce apoptosis. Our findings support non-lethal mechanism viral inactivation by demonstrating granule component, granzyme B, degrades HSV-1 immediate early protein, ICP4, which essential further gene expression. These reveal novel non-apoptotic function B context inhibiting reactivation latency.
参考文章(94)
A. B. Tullo, D. L. Easty, C. Shimeld, P. E. Stirling, J. M. Darville, Isolation of herpes simplex virus from corneal discs of patients with chronic stromal keratitis. Transactions of the ophthalmological societies of the United Kingdom. ,vol. 104, pp. 159- 165 ,(1985) , 10.1007/978-94-009-5518-9_9
George Bruening, Resistance to Infection Springer, Dordrecht. pp. 211- 240 ,(2006) , 10.1007/1-4020-3780-5_10
B T Rouse, H S Larsen, R G Russell, M P Nasisse, Role of T-lymphocytes in the pathogenesis of herpetic stromal keratitis. Investigative Ophthalmology & Visual Science. ,vol. 25, pp. 938- 944 ,(1984)
Elisabetta Miserocchi, Nadia K. Waheed, Enrique Dios, William Christen, Jesus Merayo, Manolette Roque, C.Stephen Foster, Visual outcome in herpes simplex virus and varicella zoster virus uveitis Ophthalmology. ,vol. 109, pp. 1532- 1537 ,(2002) , 10.1016/S0161-6420(02)01113-2
N A DeLuca, A M McCarthy, P A Schaffer, Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4. Journal of Virology. ,vol. 56, pp. 558- 570 ,(1985) , 10.1128/JVI.56.2.558-570.1985
Jared E. Knickelbein, Anjali J. de Souza, Richard Tosti, Preeti Narayan, Lawrence P. Kane, Cutting Edge: Inhibition of T Cell Activation by TIM-2 Journal of Immunology. ,vol. 177, pp. 4966- 4970 ,(2006) , 10.4049/JIMMUNOL.177.8.4966
Edward K. Wagner, John F. Guzowski, Jasbir Singh, Transcription of the herpes simplex virus genome during productive and latent infection. Progress in Nucleic Acid Research and Molecular Biology. ,vol. 51, pp. 123- 165 ,(1995) , 10.1016/S0079-6603(08)60878-8
David M. Knipe, The role of viral and cellular nuclear proteins in herpes simplex virus replication. Advances in Virus Research. ,vol. 37, pp. 85- 123 ,(1989) , 10.1016/S0065-3527(08)60833-7
M Kosz-Vnenchak, J Jacobson, D M Coen, D M Knipe, Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons. Journal of Virology. ,vol. 67, pp. 5383- 5393 ,(1993) , 10.1128/JVI.67.9.5383-5393.1993
G B Devi-Rao, D C Bloom, J G Stevens, E K Wagner, Herpes simplex virus type 1 DNA replication and gene expression during explant-induced reactivation of latently infected murine sensory ganglia. Journal of Virology. ,vol. 68, pp. 1271- 1282 ,(1994) , 10.1128/JVI.68.3.1271-1282.1994