MUC1: a target molecule for cancer therapy.

摘要: MUC1 is a mucin family protein, overexpressed in more than 90% of breast cancers an underglycosylated form, exposing the core peptides extracellular domain that act as potential target for antibody-mediated therapy. The highly conserved repeats 20 amino acids VNTR varies between and 125 depending on allele. Each tandem repeat contains five O-glycosylation sites have been exploited designing cancer therapeutics. repeated are masked normal cells become exposed associated mucins. characteristics MUCI epitopes constituted with carbohydrates present induce immune responses favor targeted immunotherapy. In addition, aberrant glycosylation also plays important role enhancing internalization into cytoplasm making very attractive cytoplasmic delivery system drugs other therapeutic agents. being most glandular epithelial origin, appears interventions these cancers.