Immunoglobulin binding factor: a new tumor marker for prostatic tumors.
作者： Nobuhiko Maeda , Masaharu Kamada , Toshifumi Daitoh , Masahiko Maegawa , Kohki Hirano
关键词: Prostate 、 Radioimmunoassay 、 Tumor marker 、 Endocrinology 、 Urology 、 Immunoglobulin binding 、 Adenoma 、 Antibody 、 Internal medicine 、 Prostate-specific antigen 、 Prostate cancer 、 Medicine
摘要: Human seminal plasma contains an immunoglobulin gamma binding factor (IgBF) with estimated molecular weight of 16 kD under reducing condition. IgBF was detected only in the prostate, including benign prostatic hypertrophy (BPH) and neoplasm. The present study performed to determine whether is a useful marker. Serum levels were measured patients tumors control without tumor by radioimmunoassay. prostatic-specific antigen (PSA), standard marker, also determined. prostate cancer significantly higher than those age-matched controls (P < 0.05). Also, BPH tended have elevated controls, although values not statistically significant. In patients, serum increased advancing age. There no correlation between PSA cancer. Using cut-off level at 28.5 ng/ml (2 S.D. above mean control), sensitivities 41.2% (7117) for cancer, 23.1% (6/26) BPH, 5.6% (1/18) patients. conclusion, marker diagnosis tumor, evaluating course treatment. © 1994 Wiley-Liss, Inc.
sci-hub.se 参考文章(9)
Edward E. Wallach, Nancy J. Alexander, Deborah J. Anderson, Immunology of semen Fertility and Sterility. ,vol. 47, pp. 192- 205 ,(1987) , 10.1016/S0015-0282(16)49990-5
C J Thaler, W P Faulk, J A McIntyre, Soluble antigens of IgG receptor Fc gamma RIII in human seminal plasma. Journal of Immunology. ,vol. 143, pp. 1937- 1942 ,(1989)
Z. G. Liang, M. Kamada, S. M. Mitsudo, S. S. Koide, Immunoglobulin binding factor of seminal plasma: a secretory product of human prostate. Archives of Andrology. ,vol. 28, pp. 159- 164 ,(1992) , 10.3109/01485019208987693
Charles Félix Calvo, Shinichiro Watanabe, Didier Mètivier, Anna Senik, Human monocyte cell line (U937) releases suppressive IgG‐binding factor(s) European Journal of Immunology. ,vol. 16, pp. 25- 30 ,(1986) , 10.1002/EJI.1830160106
STEVEN S. WITKIN, JON M. RICHARDS, ANN MARIE BONGIOVANNI, GERALD ZELIKOVSKY, An IgG-Fc Binding Protein in Seminal Fluid* American Journal of Reproductive Immunology. ,vol. 3, pp. 23- 27 ,(1983) , 10.1111/J.1600-0897.1983.TB00207.X
N. Maeda, M. Kamada, T. Daitoh, T. Aono, S. Futaki, Z. G. Liang, S. S. Koide, Immunoglobulin Binding Factor in Human Seminal Plasma: Immunological Function Archives of Andrology. ,vol. 31, pp. 31- 36 ,(1993) , 10.3109/01485019308988377
M. Kamada, Z. Liang, S. S. Koide, Identification of IgG and Fc-binding proteins in human seminal plasma and sperm. Archives of Andrology. ,vol. 27, pp. 1- 7 ,(1991) , 10.3109/01485019108987645
Christian J. Thaler, Peter R. McConnachie, John A. McIntyre, Inhibition of immunoglobulin (Ig)G-Fc-mediated cytotoxicity by seminal plasma IgG-Fc receptor III antigens * † Fertility and Sterility. ,vol. 57, pp. 187- 192 ,(1992) , 10.1016/S0015-0282(16)54799-2
Thomas K. Takayama, John N. Krieger, Lawrence D. True, Paul H. Lange, Recurrent Prostate Cancer Despite Undetectable Prostate Specific Antigen The Journal of Urology. ,vol. 148, pp. 1541- 1542 ,(1992) , 10.1016/S0022-5347(17)36963-X