Virulence of oral Fusobacterium nucleatum from humans and non-human primates in mice

摘要: The lethal action in Balb/c mice of 80 oral Fusobacterium nucleatum recovered from patients with adult periodontitis, healthy subjects or Cebus apella monkeys was studied. Mice were inoculated intraperitoneally each bacterial inoculum 5 x 108 CFU/ml. All the clinical isolates induced weight and coordinated movements loss. Pathological alterations liver, CNS, heart, kidney inflammatory reactions vascular congestion observed. Of all tested F. isolates, 61.2% periodontal patients, 57.1% 60% monkeys, capable killing 48h. significantly more pathogenic than ATCC 10953 25586. B. fragilis 23745 showed lethality against control mice. Our results suggest that LPS could be involved it may play an important role producing tissue damage death